Chicago O'Hare International Airport (ORD) serves Chicago; McGhee Tyson Airport (TYS) serves Knoxville.
The airports are 475 miles apart by great-circle distance.
Roame's current schedule feed shows nonstop service from ORD to TYS.
Marketing airlines listed in the current schedule, including codeshare sellers, are American Airlines (AA), Air Canada (AC), Alaska Airlines (AS), Avianca (AV), British Airways (BA), Aer Lingus (EI), Emirates (EK), Iberia (IB), Japan Airlines (JL), Lufthansa (LH), All Nippon Airways (NH), Air New Zealand (NZ), Qatar Airways (QR), Royal Jordanian (RJ) and United Airlines (UA). This list does not identify the operating airline for each flight; check the flight details before booking.
Published schedule dates span Nov 2, 2026 – Oct 31, 2027.