Flights from Knoxville to Buffalo

Did you mean Flights from Buffalo to Knoxville?

Knoxville

United States

TYS

McGhee Tyson Airport

Buffalo

United States

BUF

Buffalo Niagara International Airport

Route: Published service includes stops
Distance: 567 miles
Marketing airlines: 1 airline
Aircraft: 1 aircraft type
Dates: Feb 11 – Mar 27, 2027

Observed award fares

A sample of one-way prices for one traveler from Roame’s fare cache. Points, fees, and seats describe the same observation. Availability can change; confirm with the loyalty program before transferring points.

Departure window: 2026-10-23 – 2026-11-21.

No recent fares appear in this limited preview. This does not mean the route is sold out. Use the search controls to check other dates and routes.

Knoxville to Buffalo route overview

McGhee Tyson Airport (TYS) serves Knoxville; Buffalo Niagara International Airport (BUF) serves Buffalo.

The airports are 567 miles apart by great-circle distance.

Roame's current schedule feed lists service with stops from TYS to BUF, but no nonstop service.

Marketing airlines listed in the current schedule, including codeshare sellers, are United Airlines (UA). This list does not identify the operating airline for each flight; check the flight details before booking.

Published schedule dates span Feb 11 – Mar 27, 2027.

Marketing airlines on the Knoxville to Buffalo route

These are marketing airlines, including codeshare sellers. This list does not identify the operating airline for each flight; check the flight details before booking.

United Airlines (UA)Codeshare only

Airline alliance affiliations represented: Star Alliance

Aircraft flying from TYS to BUF

Frequently asked questions

Which airports serve the Knoxville to Buffalo route?

McGhee Tyson Airport (TYS) is the origin airport and Buffalo Niagara International Airport (BUF) is the destination airport.

How far is Buffalo from Knoxville?

TYS and BUF are approximately 567 miles apart by great-circle distance.

Are there direct flights from TYS to BUF?

No. Roame's current schedule feed lists service with stops from TYS to BUF, but no nonstop service.

Which airlines market flights from TYS to BUF?

Which aircraft fly from TYS to BUF?

Aircraft listed in the current schedule include CR5.