Flights from Buffalo to Knoxville

Did you mean Flights from Knoxville to Buffalo?

Buffalo

United States

BUF

Buffalo Niagara International Airport

Knoxville

United States

TYS

McGhee Tyson Airport

Route: No published route in current feed
Distance: 567 miles

Observed award fares

A sample of one-way prices for one traveler from Roame’s fare cache. Points, fees, and seats describe the same observation. Availability can change; confirm with the loyalty program before transferring points.

Departure window: 2026-10-23 – 2026-11-21.

No recent fares appear in this limited preview. This does not mean the route is sold out. Use the search controls to check other dates and routes.

Buffalo to Knoxville route overview

Buffalo Niagara International Airport (BUF) serves Buffalo; McGhee Tyson Airport (TYS) serves Knoxville.

The airports are 567 miles apart by great-circle distance.

Roame's current schedule feed does not list a published route from BUF to TYS; use the live results above to explore connections.

Frequently asked questions

Which airports serve the Buffalo to Knoxville route?

Buffalo Niagara International Airport (BUF) is the origin airport and McGhee Tyson Airport (TYS) is the destination airport.

How far is Knoxville from Buffalo?

BUF and TYS are approximately 567 miles apart by great-circle distance.

Are there direct flights from BUF to TYS?

No published route from BUF to TYS appears in Roame's current schedule feed. Check the live results for possible connections.