McGhee Tyson Airport (TYS) is the origin airport and San Diego International Airport (SAN) is the destination airport.
TYS and SAN are approximately 1,898 miles apart by great-circle distance.
No. Roame's current schedule feed lists service with stops from TYS to SAN, but no nonstop service.
Airlines represented in the current schedule are United Airlines (UA) and Southwest Airlines (WN).
Aircraft listed in the current schedule include Airbus A319 (319) and 7S7.