McGhee Tyson Airport (TYS) serves Knoxville; La Crosse Municipal Airport (LSE) serves La Crosse.
The airports are 677 miles apart by great-circle distance.
Roame's current schedule feed lists service with stops from TYS to LSE, but no nonstop service.
Marketing airlines listed in the current schedule, including codeshare sellers, are United Airlines (UA). This list does not identify the operating airline for each flight; check the flight details before booking.
Published schedule dates span Oct 20, 2026 – Jan 28, 2027.