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Direct flights from New Orleans to Knoxville

Did you mean Flights from Knoxville to New Orleans?

Flightmap/Flights from MSY/MSY to TYS

New Orleans

United States

MSY

Louis Armstrong New Orleans International Airport

Knoxville

United States

TYS

McGhee Tyson Airport

Route
Nonstop service available
Distance
542 miles
Marketing airlines
2 airlines
Aircraft
3 aircraft types
Dates
Oct 19 – Nov 20, 2026

Observed award fares

A sample of one-way prices for one traveler from Roame’s fare cache. Points, fees, and seats describe the same observation. Availability can change; confirm with the loyalty program before transferring points.

Departure window: 2026-10-23 – 2026-11-21.

No recent fares appear in this limited preview. This does not mean the route is sold out. Use the search controls to check other dates and routes.

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Explore these airports and cities

  • Flights from MSY
  • Flights to TYS

New Orleans to Knoxville route overview

Louis Armstrong New Orleans International Airport (MSY) serves New Orleans; McGhee Tyson Airport (TYS) serves Knoxville.

The airports are 542 miles apart by great-circle distance.

Roame's current schedule feed shows nonstop service from MSY to TYS.

Marketing airlines listed in the current schedule, including codeshare sellers, are American Airlines (AA) and Southwest Airlines (WN). This list does not identify the operating airline for each flight; check the flight details before booking.

Published schedule dates span Oct 19 – Nov 20, 2026.

Marketing airlines on the New Orleans to Knoxville route

These are marketing airlines, including codeshare sellers. This list does not identify the operating airline for each flight; check the flight details before booking.

  • American Airlines (AA)Codeshare only

Airline alliance affiliations represented: Oneworld

Aircraft flying from MSY to TYS

Frequently asked questions

Which airports serve the New Orleans to Knoxville route?

Louis Armstrong New Orleans International Airport (MSY) is the origin airport and McGhee Tyson Airport (TYS) is the destination airport.

How far is Knoxville from New Orleans?

MSY and TYS are approximately 542 miles apart by great-circle distance.

Are there direct flights from MSY to TYS?

Yes. Roame's current schedule feed shows nonstop service from MSY to TYS.

Which airlines market flights from MSY to TYS?

Marketing airlines listed in the current schedule, including codeshare sellers, are American Airlines (AA) and Southwest Airlines (WN). This list does not identify the operating airline for each flight; check the flight details before booking.

Which aircraft fly from MSY to TYS?

Aircraft listed in the current schedule include Boeing 737 MAX 8 (7M8), 7S7 and Embraer 175 (short wing) (E75).

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