Aeroenlaces Nacionales links Rionegro nonstop with Mexico City (MEX), Cancun (CUN), and Santa Lucia (NLU).
AeroMexico (SkyTeam) links Rionegro nonstop with Mexico City (MEX).
Alitalia (Star Alliance) links Rionegro nonstop with Miami (MIA).
All Nippon Airways (Star Alliance) links Rionegro nonstop with New York (JFK).
American Airlines (Oneworld) links Rionegro nonstop with Miami (MIA).
Asian Air links Rionegro nonstop with Santo Domingo (SDQ) and Punta Cana (PUJ).
Avianca (Star Alliance) links Rionegro nonstop with Miami (MIA), Mexico City (MEX), Punta Cana (PUJ), San Juan (SJU), Fort Lauderdale (FLL), New York (JFK), Santa Clara (SAL), Orlando (MCO), San Jose (SJO), and Cancun (CUN).
Copa Airlines (Star Alliance) links Rionegro nonstop with Tocumen (PTY).
Copa Airlines Colombia links Rionegro nonstop with Santo Domingo (SDQ), Punta Cana (PUJ), San Jose (SJO), Cancun (CUN), Panama City (BLB), Oranjestad (AUA), Willemstad (CUR), Guatemala City (GUA), and Montego Bay (MBJ).
Flexflight links Rionegro nonstop with Willemstad (CUR).
Frontier Airlines links Rionegro nonstop with Orlando (MCO).
Halcyon Air Cabo Verde links Rionegro nonstop with Willemstad (CUR).
JetBlue links Rionegro nonstop with San Juan (SJU) and Fort Lauderdale (FLL).
Jetsmart links Rionegro nonstop with Punta Cana (PUJ).
KLM (SkyTeam) links Rionegro nonstop with Tocumen (PTY).
TAP Portugal (Star Alliance) links Rionegro nonstop with Miami (MIA) and New York (JFK).
Turkish Airlines (Star Alliance) links Rionegro nonstop with Tocumen (PTY).
United Airlines (Star Alliance) links Rionegro nonstop with Tocumen (PTY), Miami (MIA), and Houston (IAH).
Volaris links Rionegro nonstop with Guadalajara (GDL).
WestJet links Rionegro nonstop with Mexico City (MEX).
WorldTicket links Rionegro nonstop with Santo Domingo (SDQ) and Punta Cana (PUJ).
X1 links Rionegro nonstop with Santo Domingo (SDQ) and Punta Cana (PUJ).