Aeroenlaces Nacionales flies nonstop from Rionegro to Mexico City (MEX), Cancun (CUN), and Santa Lucia (NLU).
AeroMexico (SkyTeam) flies nonstop from Rionegro to Mexico City (MEX).
Alitalia (Star Alliance) flies nonstop from Rionegro to Miami (MIA).
All Nippon Airways (Star Alliance) flies nonstop from Rionegro to New York (JFK).
American Airlines (Oneworld) flies nonstop from Rionegro to Miami (MIA).
Asian Air flies nonstop from Rionegro to Santo Domingo (SDQ) and Punta Cana (PUJ).
Avianca (Star Alliance) flies nonstop from Rionegro to Miami (MIA), Mexico City (MEX), Punta Cana (PUJ), San Juan (SJU), Fort Lauderdale (FLL), New York (JFK), Santa Clara (SAL), Orlando (MCO), San Jose (SJO), and Cancun (CUN).
Copa Airlines (Star Alliance) flies nonstop from Rionegro to Tocumen (PTY).
Copa Airlines Colombia flies nonstop from Rionegro to Santo Domingo (SDQ), Punta Cana (PUJ), San Jose (SJO), Cancun (CUN), Panama City (BLB), Oranjestad (AUA), Willemstad (CUR), Guatemala City (GUA), and Montego Bay (MBJ).
Flexflight flies nonstop from Rionegro to Willemstad (CUR).
Frontier Airlines flies nonstop from Rionegro to Orlando (MCO).
Halcyon Air Cabo Verde flies nonstop from Rionegro to Willemstad (CUR).
JetBlue flies nonstop from Rionegro to San Juan (SJU) and Fort Lauderdale (FLL).
Jetsmart flies nonstop from Rionegro to Punta Cana (PUJ).
KLM (SkyTeam) flies nonstop from Rionegro to Tocumen (PTY).
TAP Portugal (Star Alliance) flies nonstop from Rionegro to Miami (MIA) and New York (JFK).
Turkish Airlines (Star Alliance) flies nonstop from Rionegro to Tocumen (PTY).
United Airlines (Star Alliance) flies nonstop from Rionegro to Tocumen (PTY), Miami (MIA), and Houston (IAH).
Volaris flies nonstop from Rionegro to Guadalajara (GDL).
WestJet flies nonstop from Rionegro to Mexico City (MEX).
WorldTicket flies nonstop from Rionegro to Santo Domingo (SDQ) and Punta Cana (PUJ).
X1 flies nonstop from Rionegro to Santo Domingo (SDQ) and Punta Cana (PUJ).