Flights from St Louis to Knoxville

Did you mean Flights from Knoxville to St Louis?

St Louis

United States

STL

Lambert St Louis International Airport

Knoxville

United States

TYS

McGhee Tyson Airport

Route: No published route in current feed
Distance: 405 miles

Observed award fares

A sample of one-way prices for one traveler from Roame’s fare cache. Points, fees, and seats describe the same observation. Availability can change; confirm with the loyalty program before transferring points.

Departure window: 2026-10-23 – 2026-11-21.

No recent fares appear in this limited preview. This does not mean the route is sold out. Use the search controls to check other dates and routes.

St Louis to Knoxville route overview

Lambert St Louis International Airport (STL) serves St Louis; McGhee Tyson Airport (TYS) serves Knoxville.

The airports are 405 miles apart by great-circle distance.

Roame's current schedule feed does not list a published route from STL to TYS; use the live results above to explore connections.

Frequently asked questions

Which airports serve the St Louis to Knoxville route?

Lambert St Louis International Airport (STL) is the origin airport and McGhee Tyson Airport (TYS) is the destination airport.

How far is Knoxville from St Louis?

STL and TYS are approximately 405 miles apart by great-circle distance.

Are there direct flights from STL to TYS?

No published route from STL to TYS appears in Roame's current schedule feed. Check the live results for possible connections.