Vignette Collection Hotel Spero

At Hotel Spero, discover a distinctive retreat tucked into the heart of vibrant Union Square. Steps from San Francisco’s most iconic neighborhoods, dining, attractions, and culture, the city unfolds just outside our hotel doors. Stroll to the Powell Street cable cars, enjoy a show in the Theater District or explore nearby Nob Hill and North Beach. Inside, historic character blends effortlessly with modern design, creating a refined yet relaxed place to settle in, recharge, and explore. Whether you’re wandering the city for a weekend escape, savoring a slower stay, a business meeting or a meaningful celebration, Hotel Spero offers an inviting setting shaped by warmth, style, and intentional hospitality.