Aegean Airlines (Star Alliance) links Frankfurt-am-Main nonstop with Toronto (YYZ) and Montreal (YUL).
Air Canada (Star Alliance) links Frankfurt-am-Main nonstop with Calgary (YYC), Toronto (YYZ), San Francisco (SFO), Seattle (SEA), Chicago (ORD), Boston (BOS), Dulles (IAD), Montreal (YUL), Denver (DEN), Houston (IAH), Vancouver (YVR), Newark (EWR), Halifax (YHZ), and Raleigh/Durham (RDU).
Air China (Star Alliance) links Frankfurt-am-Main nonstop with San Jose (SJO).
Air France (SkyTeam) links Frankfurt-am-Main nonstop with Atlanta (ATL), New York (JFK), and Detroit (DTW).
Air India (Star Alliance) links Frankfurt-am-Main nonstop with Dulles (IAD).
Air New Zealand (Star Alliance) links Frankfurt-am-Main nonstop with San Francisco (SFO), New York (JFK), Los Angeles (LAX), Houston (IAH), and Vancouver (YVR).
Alaska Airlines (Oneworld) links Frankfurt-am-Main nonstop with San Francisco (SFO), Seattle (SEA), New York (JFK), Chicago (ORD), Boston (BOS), Los Angeles (LAX), Las Vegas (LAS), Anchorage (ANC), and Portland (PDX).
American Airlines (Oneworld) links Frankfurt-am-Main nonstop with Dallas-Fort Worth (DFW) and Charlotte (CLT).
Austrian Airlines (Star Alliance) links Frankfurt-am-Main nonstop with Calgary (YYC), Toronto (YYZ), San Francisco (SFO), Seattle (SEA), Los Angeles (LAX), Montreal (YUL), Orlando (MCO), Cancun (CUN), Tampa (TPA), Punta Cana (PUJ), Philadelphia (PHL), Newark (EWR), Las Vegas (LAS), Halifax (YHZ), Fort Myers (RSW), Miami (MIA), Mexico City (MEX), Minneapolis (MSP), and Edmonton (YEG).
British Airways (Oneworld) links Frankfurt-am-Main nonstop with Dallas-Fort Worth (DFW) and Charlotte (CLT).
Brussels Airlines (Star Alliance) links Frankfurt-am-Main nonstop with Calgary (YYC), Atlanta (ATL), San Francisco (SFO), Seattle (SEA), New York (JFK), Boston (BOS), Los Angeles (LAX), Montreal (YUL), Orlando (MCO), Tampa (TPA), Punta Cana (PUJ), Philadelphia (PHL), Newark (EWR), Las Vegas (LAS), Halifax (YHZ), Fort Myers (RSW), Minneapolis (MSP), and Edmonton (YEG).
Condor links Frankfurt-am-Main nonstop with Calgary (YYC), Toronto (YYZ), San Francisco (SFO), Seattle (SEA), New York (JFK), Chicago (ORD), Boston (BOS), Los Angeles (LAX), Cancun (CUN), Vancouver (YVR), Punta Cana (PUJ), Bridgetown (BGI), La Romana (LRM), Las Vegas (LAS), Montego Bay (MBJ), San Jose (SJO), Anchorage (ANC), Portland (PDX), Puerto Plata (POP), Scarborough (TAB), San Jose del Cabo (SJD), St. George (ANU), Fort-de-France (FDF), and Tocumen (PTY).
Croatia Airlines (Star Alliance) links Frankfurt-am-Main nonstop with Toronto (YYZ), Montreal (YUL), and Vancouver (YVR).
Cubana De Aviacion links Frankfurt-am-Main nonstop with Havana (HAV) and Holguin (HOG).
Delta Air Lines (SkyTeam) links Frankfurt-am-Main nonstop with Atlanta (ATL), New York (JFK), and Detroit (DTW).
Discover Airlines (Star Alliance) links Frankfurt-am-Main nonstop with Calgary (YYC), Seattle (SEA), Orlando (MCO), Cancun (CUN), Tampa (TPA), Punta Cana (PUJ), Bridgetown (BGI), Philadelphia (PHL), La Romana (LRM), Las Vegas (LAS), Montego Bay (MBJ), Halifax (YHZ), Fort Myers (RSW), Newburgh (SWF), Minneapolis (MSP), and Edmonton (YEG).
EgyptAir (Star Alliance) links Frankfurt-am-Main nonstop with Toronto (YYZ) and Montreal (YUL).
Emirates links Frankfurt-am-Main nonstop with Cancun (CUN), Punta Cana (PUJ), Montego Bay (MBJ), and Puerto Plata (POP).
Ethiopian Airlines (Star Alliance) links Frankfurt-am-Main nonstop with New York (JFK).
Etihad Airways links Frankfurt-am-Main nonstop with Seattle (SEA) and St. George (ANU).
Finnair (Oneworld) links Frankfurt-am-Main nonstop with Dallas-Fort Worth (DFW) and Charlotte (CLT).
Gulf Air links Frankfurt-am-Main nonstop with Dallas-Fort Worth (DFW).
Iberia (Oneworld) links Frankfurt-am-Main nonstop with Dallas-Fort Worth (DFW) and Charlotte (CLT).
KLM (SkyTeam) links Frankfurt-am-Main nonstop with Atlanta (ATL), New York (JFK), and Detroit (DTW).
Lufthansa (Star Alliance) links Frankfurt-am-Main nonstop with Calgary (YYC), Toronto (YYZ), Dallas-Fort Worth (DFW), Atlanta (ATL), San Francisco (SFO), Seattle (SEA), New York (JFK), Chicago (ORD), Boston (BOS), Dulles (IAD), Los Angeles (LAX), Detroit (DTW), Montreal (YUL), Denver (DEN), Houston (IAH), Orlando (MCO), Cancun (CUN), Tampa (TPA), Vancouver (YVR), Punta Cana (PUJ), Philadelphia (PHL), Newark (EWR), Las Vegas (LAS), Halifax (YHZ), Raleigh/Durham (RDU), St Louis (STL), Austin (AUS), Fort Myers (RSW), San Jose (SJO), Miami (MIA), Mexico City (MEX), Columbus (CMH), Minneapolis (MSP), and Edmonton (YEG).
Singapore Airlines (Star Alliance) links Frankfurt-am-Main nonstop with Toronto (YYZ), New York (JFK), and Montreal (YUL).
SriLankan Airlines (Oneworld) links Frankfurt-am-Main nonstop with Toronto (YYZ) and Dallas-Fort Worth (DFW).
Swiss International Air Lines (Star Alliance) links Frankfurt-am-Main nonstop with Calgary (YYC), Seattle (SEA), Orlando (MCO), Cancun (CUN), Tampa (TPA), Vancouver (YVR), Punta Cana (PUJ), Philadelphia (PHL), Las Vegas (LAS), Halifax (YHZ), Fort Myers (RSW), Mexico City (MEX), Minneapolis (MSP), and Edmonton (YEG).
TAROM (SkyTeam) links Frankfurt-am-Main nonstop with Calgary (YYC), Toronto (YYZ), San Francisco (SFO), Seattle (SEA), New York (JFK), Chicago (ORD), Boston (BOS), Los Angeles (LAX), Vancouver (YVR), Las Vegas (LAS), Anchorage (ANC), and Portland (PDX).
Thai Airways (Star Alliance) links Frankfurt-am-Main nonstop with Toronto (YYZ), Dallas-Fort Worth (DFW), Atlanta (ATL), New York (JFK), Chicago (ORD), Boston (BOS), Dulles (IAD), Montreal (YUL), and Miami (MIA).
United Airlines (Star Alliance) links Frankfurt-am-Main nonstop with Toronto (YYZ), Dallas-Fort Worth (DFW), Atlanta (ATL), San Francisco (SFO), Seattle (SEA), New York (JFK), Chicago (ORD), Boston (BOS), Dulles (IAD), Los Angeles (LAX), Detroit (DTW), Montreal (YUL), Denver (DEN), Houston (IAH), Orlando (MCO), Tampa (TPA), Vancouver (YVR), Philadelphia (PHL), Newark (EWR), Las Vegas (LAS), Raleigh/Durham (RDU), St Louis (STL), Austin (AUS), Fort Myers (RSW), Miami (MIA), Columbus (CMH), and Minneapolis (MSP).
Vietnam Airlines (SkyTeam) links Frankfurt-am-Main nonstop with Atlanta (ATL), New York (JFK), and Detroit (DTW).
Virgin Atlantic (SkyTeam) links Frankfurt-am-Main nonstop with Atlanta (ATL), New York (JFK), and Detroit (DTW).
WestJet links Frankfurt-am-Main nonstop with Calgary (YYC), Toronto (YYZ), and Vancouver (YVR).